Diazepam is a derivative of benzodiazepine. Its chemical name is 7-chloro-1,3-dihydro-1- methyl-5-phenyl-2H-1,4-benzodiazepine-2-one. Diazepam is the generic name, whose brand name is Valium. It is a crystalline compound insoluble in the water. Its color ranges from colorless to yellow.
Orally administered tablets are available, which contains the Diazepam (2mg, 5mg, and 10mg) as the active ingredient and pregelatinized corn starch, colloidal silicon dioxide, microcrystalline cellulose, magnesium stearate, and sodium lauryl sulfate as the inactive ingredients.
Diazepam treats anxiety disorder and provides short term relief from the symptoms of anxiety.
Diazepam 5mg tablets can also be useful in providing relief from acute alcohol withdrawal symptoms. It can treat tremors, agitation, hallucinosis, acute delirium tremens, and other severe symptoms caused by alcohol withdrawal.
Diazepam 5mg and Diazepam 10mg tablets help relieve the muscle cramps, inflammation of muscles or joints, secondary trauma, upper motor neuron disorders, cerebral palsy, paraplegia, stiff-man syndrome, and athetosis.
Diazepam tablets also relieve convulsive disorders when combined with other medications and therapies.
People use Diazepam for Sleep despite it is not a sleep medication. Diazepam is a benzodiazepine and hence causes the sedative effects, which can result in drowsiness and sleep. But you should not use Diazepam for Sleep as it can cause addiction or other side effects.
Lorazepam vs Diazepam
Lorazepam and Diazepam both are useful in treating anxiety and other psychiatric disorders. They are the derivatives of benzodiazepines and thus work similarly.
The significant difference between Lorazepam and Diazepam is that lorazepam leaves the patient’s system quickly, which reduces the chances of side effects (including addiction, memory issues, depression, and fatigue) and toxicity. Lorazepam, when compared to Diazepam, has lesser contraindications and unfavorable interactions with other medications.
Apart from these two factors, Lorazepam and Diazepam works in the same way and have similar side effects and dosage regimes, etc.
Individualize the dosage of Diazepam for maximized effectiveness. Doctors prescribe the medication and schedule the dosage regime according to the severity of health conditions and patients’ personal needs.
|Anxiety disorder and symptoms of anxiety||2-10mg given two to four times a day.|
|Acute alcohol withdrawal||10mg given three to four times in the first 24 hours. Then reducing to 5mg three to four times a day.|
|Skeletal muscle spasm||2-10mg given three to four times a day.|
|Convulsive disorders||2-10mg given two to four times a day.|
|Debilitating disease||2-2.5mg given three to four times a day initially. Gradually increasing the dose as needed.|
Diazepam forms and strengths
|2mg||Round, scored tablets.||White.||MYLAN over 271 on one side and scored on the other side.||NDC 0378-0271-01 bottles of 100 tablets
NDC 0378-0271-05 bottles of 500 tablets
|5mg||Round, scored tablets.||Orange.||MYLAN over 345 on one side and scored on the other side.||NDC 0378-0345-01 bottles of 100 tablets
NDC 0378-0345-05 bottles of 500 tablets
|10mg||Round, scored tablets.||Green.||MYLAN over 477 on one side and scored on the other side.||NDC 0378-0477-01 bottles of 100 tablets
NDC 0378-0477-05 bottles of 500 tablets
Diazepam half-life after the initial distribution is up to 48 hours. The active metabolite N-desmethyldiazepam has an elimination half-life of up to 100 hours. Diazepam is excreted majorly in the urine. The removal of Diazepam in young adults is 20-30ml per minute.
Diazepam half-life in the children (3-8 years old) is up to 18 hours.
For the infants or newborns, Diazepam half-life is around 30 hours.
The elimination half-life increases by 1 hour (approximately) for each year of age, beginning at the age of 20 years of age with a half-life of 20 hours.
Diazepam Side Effects
The common side effects of Diazepam include:
- Slurred speech
- Gastrointestinal disorders
- Blurred vision
- Hyper excited state
- Sleep disorders
- Changes in libido
- Urinary retention
- Skin allergies and reactions
- Dry mouth
Diazepam overdose usually acts on the Central Nervous System (CNS), resulting in severe effects ranging from drowsiness to even coma.
The mild Diazepam Overdose symptoms are:
The severe cases of Diazepam Overdose can cause:
- Decreased reflexes
- Respiratory depression
In the case of Diazepam Overdose, if any of the above symptoms occur, contact your doctor immediately and seek medical help.