Subutex is buprenorphine, a partial agonist at the mu-opioid receptor, tablet with corn starch, lactose, mannitol, povidone K30, sodium citrate, magnesium stearate, and citric acid as the inactive ingredients.
Sublingual Buprenorphine tablets are the generic Subutex approved under the Abbreviated New Drug Application (ANDA) by the FDA (Food & Drug Administration).
When you Buy Subutex Online, the usual Subutex price ranges from $40 to $150. The street Subutex price is generally $1.5 to $3 per tablet. Common street names of Subutex are strips, sub, subs, buse, oranges, sobos, and stops.
Subutex (buprenorphine) has a long half-life. Subutex half-life is generally 24 to 42 hours. It is broken down by the liver and excreted in the kidney to pass out through urine and feces.
Buy Subutex Online for the treatment of opioid dependence. It treats the addiction or dependence of opioids in adjunct with psychosocial support and counseling therapies.
Subutex pills also help in preventing the withdrawal symptoms caused by opioids.
Subutex dose is taken sublingually, one pill, only once a day. Take medicine as a whole. Do not cut, chew, split, or swallow the Subutex pill. Do not drink or eat until the pill fully dissolves.
Subutex pill is preferred to use only during induction, as it does not contain naloxone. Take the following points into consideration before the start of induction:
- Type of opioid dependence or addiction
- Time since last opioid use
- Degree or level of dependence.
Maintenance of Subutex Dose:
- Subutex dose is favorable for maintenance treatment.
- For the patients who cannot tolerate the presence of naloxone, progressively adjust the Subutex dose with increment or decrement of 2mg or 4mg.
- The maintenance Subutex dose generally ranges from 4mg to 24mg a day, depending upon the needs of the patient. The recommended daily dose is 16mg of buprenorphine per day.
- Subutex dose higher than 24mg does not provide any clinical advantage.
Forms and Strength
The Subutex pills are available in the forms and strengths of:
|Buprenorphine 2 mg||Oval flat beveled edged sublingual tablet, content expressed in terms of free base.||White.||“B2”||NDC 12496-1278-2 in the bottles of 30 tablets.|
|Buprenorphine 8 mg||Oval flat beveled edged sublingual tablet, content expressed in terms of free base.||White.||“B8”||NDC 12496-1310-2 in the bottles of 30 tablets.|
Subutex Side Effects
The adverse side effects of Subutex include:
- Respiratory depression
- Central Nervous System (CNS) depression
- Neonatal opioid withdrawal syndrome
- Opioid withdrawal
- Adrenal inefficiency
- Hypersensitivity reactions
- Increased cerebrospinal fluid pressure
- Orthostatic hypotension
- Increased Intracholedochal Pressure.
The buprenorphine in Subutex is a partial agonist at the mu-opioid receptor. Its prolonged doses can cause dependence on the opioid type. Subutex causes mild withdrawal symptoms upon suddenly discontinuing the medication. The withdrawal symptoms are milder compared to the full agonist, and prevention is easier at the onset.
Subutex interacts with the below mentioned drugs to create dangerous effects for the user.
Central Nervous System Depressant:
- Non-benzodiazepine sedatives
- Muscle relaxants
- General anesthetics
- Other opioids
Inhibitors of CYP3A4:
- Macrolide antibiotics
- Azole antifungal agents
- Protease inhibitors.
Antiretrovirals: Protease inhibitors (PIs):
Monoamine Oxidase Inhibitors (MAOIs):
Acute overdose symptoms are:
- Pinpoint pupils
- Respiratory depression
In the case of Subutex high or overdose, monitor the respiratory and cardiac status of the patient. If the respiratory condition is depressed, provide alternative respiration. Re-establish the adequate ventilation. Seek medical help for controlling the respiratory and cardiac condition of the patient.